General Information

  • ID:  hor001341
  • Uniprot ID:  A0A0F7CWL3
  • Protein name:  GnIH-RP2
  • Gene name:  NPVF
  • Organism:  Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Coturnix (genus), Perdicinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001664 G protein-coupled receptor binding
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0032100 positive regulation of appetite; GO:0033685 negative regulation of luteinizing hormone secretion
  • GO CC:  GO:0005576 extracellular region; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043204 perikaryon

Sequence Information

  • Sequence:  SPLARSSIQSLLNLPQ
  • Length:  16(137-152)
  • Propeptide:  MEIISTQKFILLTLATVAFLTPHGACLDELMKSSLESREDDDDKYYEIKDSILEEKQRSLNFEEMKDWGSKNFMKVNTPTVNKVPNSVANLPLRFGRSNPEERSIKPSAYLPLRFGRAFGESLSRRAPNLSNRSGRSPLARSSIQSLLNLPQRFGKSVPISLSQGVQESEPGM
  • Signal peptide:  MEIISTQKFILLTLATVAFLTPHGAC
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A0F7CWL3-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001341_AF2.pdbhor001341_ESM.pdb

Physical Information

Mass: 199172 Formula: C75H130N22O24
Absent amino acids: CDEFGHKMTVWY Common amino acids: LS
pI: 10.55 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 6
Hydrophobicity: 0.63 Boman Index: -1983
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 128.13
Instability Index: 12787.5 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  20298575
  • Title:  Neuropeptidomic Analysis of the Embryonic Japanese Quail Diencephalon